PUBLICATIONS

  1. Viviers, C., du Toit, A., Perold, W., Loos, B. and Hofmeyr J-H.S. A resistive biosensor for the detection of lc3 protein in autophagy. IEEE Sensors Journal. Accepted.

  2. Hämälistö, S., Stahl, J.L., Favaro, E., Yang, Q., Liu, B., Christoffersen L., et al. 2020. Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation. Nature Communications. doi:10.1038/s41467-019-14009-0.

  3. Loos, B., Klionsky, D.J., Du Toit, A., and Hofmeyr, J-H.S. 2019. On the relevance of precision autophagy flux control in vivo – Points of departure for clinical translation. Autophagy. doi: 10.1080/15548627.2019.1687211.

  4. Theart, R.P., Loos, B., and Niesler, T.R. 2019. Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs. PLoS ONE 14(11): e0225141. doi: 10.1371/journal.pone.0225141

  5. Bleloch, J.S., duToit, A., Gibhard, L., Kimani, S., Ballim, R.D., Lee, M., et al. 2019. The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells. Cell Death Discovery. 5. doi:10.1038/s41420-019-0139-9.

  6. Blignaut, M., Loos, B., Botchway, S.W., Parker, A.W., and Huisamen B. 2019. Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation. Scientific Reports. 9:4782. doi:10.1038/s41598-019-41108-1.

  7. Kriel J, Loos B. The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death. Cell Death & Differentiation. 2019. 26:640-652. doi:10.1038/s41418-018-0267-4.

  8. Neethling, A., Engelbrecht, L., Loos, B., Kinnear, C., Theart, R., Abrahams, S., et al. 2019. Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex. Experimental Cell Research. 375:72-79. doi:10.1016/j.yexcr.2018.12.022.

  9. Du Toit, A., De Wet, S., Hofmeyr, J-H.S., Müller-Nedebock, K.K., and Loos, B. 2018. The precision control of autophagic flux and vesicle dynamics—a micropattern approach. Cells. 7:94. doi:10.3390/cells7080094.

  10. Thomas, T., Davis, T., Loos, B., Sishi, B., Huisamen, B., Strijdom, H., Engelbrecht, A-M. 2018. Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells. Cell Biochemistry and Function. 36:65-79. doi:10.1003/cbf.3318.

  11. Kriel, J., Müller-Nedebock, K., Maarman, G., Mbizana, S., Ojuka, E., Klumperman, B., and Loos, B. 2018. Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics. Scientific Reports. 8:10348. doi:10.1038/s41598-018-28590-9.

  12. Davis, T., van Niekerk, G., Peres, J., Prince, S., Loos, B., Engelbrecht, A-M. 2018. Doxorubicin resistance in breast cancer: A novel role for the human protein AHNAK. Biochemical Pharmacology. 148:174-183. doi: 10.1016/j.bcp.2018.01.012

  13. Theart, R., Loos, B., Powrie, Y.S.L., and Niesler T.R. 2018. Improved region of interest selection and colocalization analysis in three-dimensional fluorescence microscopy samples using virtual reality. PLOS ONE. 13:e0201965. doi:10.1371/journal.pone.0201965. eCollection 2018.

  14. Du Toit, A, Hofmeyr, JH, Loos B. 2018. Measuring Autophagosome Flux. Autophagy, 14:1060-1071. doi:10.1080/15548627.2018.1469590.

  15. Govender, J., Loos, B., Marais, E., and Engelbrecht, A.M. 2018. Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity? Toxicology and Applied Pharmacology. 358:86-101. doi:10.1016/j.taap.2018.06.031.

  16. Bhat, P., Kriel, J., Priya, B.S., Basappa, Shivananju, N.S. & Loos, B. 2018. Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization. Biochemical Pharmacology. 147:170–182. doi: 10.1016/j.bcp.2017.11.021

  17. van Niekerk, G., du Toit, A., Loos, B. and Engelbrecht, A.M. 2018. Nutrient excess and autophagic deficiency: explaining metabolic diseases in obesity. Metabolism. 82:14-21. doi: 10.1016/j.metabol.2017.12.

  18. Mbizana, S., Hlalele, L., Pfukwa, R., du Toit, A., Lumkwana, D., Loos, B., and Klumperman, B. 2018. Synthesis and cell interaction of statistical l-arginine–glycine–l-aspartic acid terpolypeptides. Biomacromolecules. 19:3058-3066. doi:10.1021/acs.biomac.8b00620.

  19. Loos, B., Klionsky, D.J. and Wong, E. 2017. Augmenting brain metabolism to increase macro- and chaperone-mediated autophagy for decreasing neuronal proteotoxicity and aging. Progress in Neurobiology. 156:90-106. doi:10.1016/j.pneurobio.2017.05.001.

  20. Lumkwana, D., du Toit, A., Kinnear, C. and Loos, B. 2017. Autophagic flux control in neurodegeneration: Progress and precision targeting—Where do we stand? Progress in Neurobiology. 153:64-85. doi:10.1016/j.pneurobio.2017.03.006. 

  21. Van der Merwe, C., Van Dyk, H.C., Engelbrecht, L., van der Westhuizen, F.H., Kinnear, C., Loos, B. and Bardien, S., 2016. Curcumin rescues a PINK1 knock down SH-SY5Y cellular model of Parkinson’s disease from mitochondrial dysfunction and cell death. Molecular Neurobiology. 54:2752–2762. doi:10.1007/s12035-016-9843-0.

  22. Theart, R.P., Loos, B. and Niesler, T.R., 2017. Virtual reality assisted microscopy data visualization and colocalization analysis. BMC Bioinformatics, 18:64. doi:10.1186/s12859-016-1446-2.

  23. Kannan, M., Bayam, E., Wagner, C., Rinaldi, B., Kretz, P.F., et al. 2017. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. PNAS. 114:E9308-E9317. doi:10.1073/pnas.1713625114.

  24. Swart C, Khoza A, Khan K, Roux SL, du Plessis A, et al. 2017. Investigating basal autophagic activity in brain regions associated with neurodegeneration using in vivo and ex vivo models. J Alzheimers Dis Parkinsonism 7:337. doi:10.4172/2161-0460.1000337.

  25. Haylett, W., Swart, C., van der Westhuizen, F., van Dyk, H., Van der Merwe, L., van der Merwe, C., Loos, B., Carr, J., Kinnear, C. and Bardien, S. 2016. Altered mitochondrial respiration and other features of mitochondrial function in Parkin-mutant fibroblasts from Parkinson’s disease patients. Parkinson’s Disease. 2016:1819209. doi:10.1155/2016/1819209.

  26. Swart, C., Du Toit, A. and Loos, B. 2016. Autophagy and the invisible line between life and death. European Journal of Cell Biology. 95:598-610. doi:10.1016/j.ejcb.2016.10.005.

  27. van Niekerk, G., Loos, B., Nell, T. and Engelbrecht, A.M., 2016. Autophagy—a free meal in sickness-associated anorexia. Autophagy. 12:727-734. doi:10.1080/15548627.2016.1147672.

  28. Ntsapi, C. and Loos, B. 2016. Caloric restriction and the precision-control of autophagy: A strategy for delaying neurodegenerative disease progression. Experimental Gerontology. 83:97-111. doi:10.1016/j.exger.2016.07.014.

  29. van Niekerk, G., Loos, B., Nell, T. and Engelbrecht, A.M. 2016. Cancer tolerance, resistance, pathogenicity and virulence: deconstructing the disease state. Future Oncology. 12:1369-1380. doi:10.2217/fon-2015-0024.

  30. Neethling, A., Mouton, J., Loos, B., Corfield, V., de Villiers, C. and Kinnear, C. 2016. Filamin C: A novel component of the KCNE2 interactome during hypoxia. Cardiovascular Journal of Africa. 27:4-11. doi:10.5830/cvja-2015-049.

  31. Klionsky, D.J., et al. 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12:1-222. doi: 10.1080/15548627.2015.1100356.

  32. Leisching, G., Loos, B., Botha, M. and Engelbrecht, A-M. 2015. A nontoxic concentration of cisplatin induces autophagy in cervical cancer: selective cancer cell death with autophagy inhibition as an adjuvant treatment. International Journal of Gynecological Cancer. 25(3):380-388. doi:10.1097/IGC.0000000000000365.

  33. Dicks, L.M.T., Botha, M., Loos, B. and Smith, C. 2015. Adhesion of Lactobacillus reuteri strain Lr1 to equine epithelial cells and competitive exclusion of Clostridium difficile from the gastro-intestinal tract of horses. Annals of Microbiology. 65:1087–1096. doi: 10.1007/s13213-014-0954-4.

  34. Mouton,J., Loos, B., Moolman-Smook, J.C. and Kinnear, C.J. Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction. Experimental Cell Research: 331:338-351. doi: 10.1016/j.yexcr.2014.11.006.

  35. Leisching, G., Loos, B., Botha, M. and Engelbrecht, A.M. 2015. Bcl-2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose-dependent toxicity and resistance. Journal of Translational Medicine. 13:328. doi:10.1186/s12967-015-0689-4.

  36. van der Merwe, C., Jalali Sefid Dashti, Z., Christoffels, A., Loos, B. and Bardien, S. 2015. Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1. European Journal of Neuroscience. 41:1113-1125. doi: 10.1111/ejn.12872.

  37. Govender, J., Loos, B. and Engelbrecht, A.M. 2015. Melatonin: a protective role against doxorubicin-induced cardiotoxicity. Future Oncology. 11:2003-6. doi:10.2217/fon.15.48.

  38. Leisching, G., Loos, B., Nell, T. and Engelbrecht, A.M. 2015. Sutherlandia frutescens treatment induces apoptosis and modulates the PI3-kinase pathway in colon cells. South African Journal of Botany. 100:20-26. doi:10.1016/j.sajb.2015.04.013.

  39. Leisching, G., Loos, B., Botha, M.H. and Engelbrecht, A.M. 2015. The role of mTOR during cisplatin treatment in an in vitro and ex vivo model of cervical cancer. Toxicology. 335: DOI: 72-78. doi:10.1016/j.tox.2015.07.010.

  40. Davis, T.A., Loos, B. and Engelbrecht, A.M. 2014. AHNAK: The giant jack of all trades. Cellular Signalling. 26:2683-2693. doi:10.1016/j.cellsig.2014.08.017.

  41. Loos, B., du Toit, A. and Hofmeyr, J-H.S. 2014. Defining and measuring autophagosome flux—concept and reality. Autophagy. 10:2087-2096. doi:10.4161/15548627.2014.973338.

  42. Loos, B. 2014. Autophagy researchers. 2014. Autophagy 10:1149-1152. doi:10.4161/auto.28812.


 

Book Chapters

  1. Maduna, T., du Toit, A., Loos, B. Macro- and chaperone-mediated autophagy in aging. The Neuroscience of Aging. Book 2: The neuroscience of aging and its interconnections with genetics, neurology, behavior, and diet. Edited by Colin Martin and Victor Preedy. Elsevier Inc. Accepted.

  2. du Toit, A., Loos, B., Hofmeyr, J.H.S. 2020. Supply and demand analysis of autophagy. In: Nagrath D. (eds) Metabolic Flux Analysis in Eukaryotic Cells. Methods in Molecular Biology, vol 2088. Humana, New York, NY. doi:10.1007/978-1-0716-0159-4_16.

  3. Ntsapi, C., du Toit, A., and Loos, B. 2019. Dietary impact on neuronal autophagy control and brain health, Feed your mind - How Does Nutrition Modulate Brain Function throughout Life?, Clémentine Bosch-Bouju, Sophie Layé and Véronique Pallet, IntechOpen, doI: 10.5772/intechopen.85228.

  4. Ntsapi, C., Lumkwana, D., Swart C., du Toit, A. and Loos, B. 2018. Chapter Seven - New insights into autophagy dysfunction related to amyloid beta toxicity and neuropathology in Alzheimer’s disease. IRCMB. 336:321-361.

  5. Swart C., du Toit, A. and Loos, B. 2017. Cross-talk between autophagy and cell death pathways – towards understanding a system. Autophagy and Signaling. ISBN 9781498731898. Taylor & Francis, 2017. Edited by Esther Wong. 

  6. du Toit, A., Hofmeyr, J.H.S. and Loos, B. 2017. Chapter 2 - Methods for measuring autophagosome flux – Impact and Relevance. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. ISBN 978-0-12-805420-8; 2017. Edited by E. Hayat. 

  7. Ntsapi, C., Swart C., Lumkwana, D. and Loos, B. 2016. Autophagic flux failure in neurodegeneration: Identifying the defect & compensating flux offset. Autophagy in Current Trends in Cellular Physiology and Pathology. IntechOpen. ISBN 978-953-51-2726-8. Edited by Nikolai Gorbunov and Marion Schneider. doi:10.5772/64197.

  8. Loos B. Autophagic Flux and Cell Death. 2015. 20 Years of Cell Death. The International Cell Death Society.  Editors: Richard A Lockshin and Zahra Zakeri.  ISBN: 978-0-9894674-5-2.

  9. Loos, B., Hofmeyr, J.H., Müller-Nedebock, K., Boonzaaier, L. and Kinnear C. 2014. Autophagic flux, fusion dynamics and cell death. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 3:39-56. Edited by E. Hayat. ISBN 9780124055292. Elsevier Inc. doi:10.1016/B978-0-12-405529-2.00002-0.  

  10. Loos, B., Sishi, B. and Engelbrecht, A.M. 2014. Chapter 22 - Role of Autophagy in Heart Disease. Autophagy. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 2: 315-328. Role In General Diseases. Edited by E. Hayat. ISBN: 978-0-12-405877-4, Elsevier Inc. Doi:10.1016/B978-0-12-405877-4.00022-6

  11. Engelbrecht, A-M. and Loos, B. 2012. Glucocorticoid-Induced Cardioprotection: A Novel Role For Autophagy. Glucocorticoids - New Recognition of Our Familiar Friend. Edited by Xiaoxiao Qian, ISBN 978-953-51-0872-6; InTech Publishing. doi:10.5772/52406.

 

https://orcid.org/0000-0002-5517-373X

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Contact

email: bloos@sun.ac.za

phone: +27 21 808 9196